abstract：OBJECTIVE:A retrospective study was conducted in order to elucidate the clinicopathological significance of fibrous bodies, a hallmark of the sparsely granulated variant of GH-producing pituitary adenomas. METHODS:A total of 37 acromegalic patients, 14 men and 23 women, with pure GH adenomas were studied. Immunohistoc...

journal_title：Clinical endocrinology

authors： Nishioka H,Haraoka J,Akada K

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that patients with hyperprolactinaemia due to biologically inactive macroprolactin will not show the characteristically increased dopaminergic inhibition of TSH release seen in patients with microprolactinomas secreting biologically active monomeric PRL. DESIGN:Comparison of the TSH an...

journal_title：Clinical endocrinology

authors： Pinto LP,Hanna FW,Evans LM,Davies JS,John R,Scanlon MF

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:The diagnostic impact of chromogranin A (CgA) measurement has been studied in various neuroendocrine tumours (NET) such as pheochromocytomas, gastrinomas and neuroblastomas. Clinically nonfunctioning pituitary adenomas (NFPA) are generally diagnosed on tumoural symptoms or hypopituitarism and, except for gona...

journal_title：Clinical endocrinology

authors： Gussi IL,Young J,Baudin E,Bidart JM,Chanson P

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:Given the important role of the beta2-adrenoceptor (beta2-AR) in lipid mobilization and the lack of studies in Southern European countries, the aim of this study was to investigate the role of the glutamine 27 glutamic acid (Gln27Glu) beta2-AR polymorphism in the susceptibility to obesity and its metabolic co...

journal_title：Clinical endocrinology

authors： González Sánchez JL,Proenza AM,Martínez Larrad MT,Ramis JM,Fernández Pérez C,Palou A,Serrano Ríos M

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of maternal hypothyroxinaemia during early gestation (fT4 below the lowest tenth percentile and TSH within the reference range: 0.15-2.0 mIU/l) on infant development, together with any subsequent changes in fT4 during gestation. DESIGN:A prospective 3-year follow-up study of pregnant w...

journal_title：Clinical endocrinology

authors： Pop VJ,Brouwers EP,Vader HL,Vulsma T,van Baar AL,de Vijlder JJ

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:To compare ultrasonography and 99mTc thyroid scintigraphy for the aetiologic diagnosis of permanent congenital hypothyroidism (CH). STUDY DESIGN:Eighty-eight consecutive patients with CH were recruited at an endocrinology outpatient clinic and submitted to high-frequency ultrasonography and to 99mTc scintigr...

journal_title：Clinical endocrinology

authors： Kreisner E,Camargo-Neto E,Maia CR,Gross JL

更新日期：2003-09-01 00:00:00

abstract：:Millions of women are treated with hormone replacement therapy (HRT) for relief of menopausal symptoms, including vasomotor flushes and sweats for which oestrogen is uniquely and highly effective. Others may continue longer-term treatment in the hope that HRT will help to prevent chronic disease. The preservation of b...

journal_title：Clinical endocrinology

authors： Armitage M,Nooney J,Evans S

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVE:In the present study we have performed a grey-scale quantitative analysis of thyroid echogenicity in the patients affected by Hashimoto's thyroiditis (HT), obtaining a numerical estimate of the degree of hypoechogenicity associated with the appearance of thyroid dysfunction. MATERIALS AND METHODS:The study g...

journal_title：Clinical endocrinology

authors： Mazziotti G,Sorvillo F,Iorio S,Carbone A,Romeo A,Piscopo M,Capuano S,Capuano E,Amato G,Carella C

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVE:To compare the relative utility of GH stimulation tests and assays of spontaneous GH secretion as predictors of change in height standard deviation score at the end of GH treatment in children with short stature. PATIENTS AND METHODS:We retrospectively studied 116 children (67 boys and 49 girls) with subnorm...

journal_title：Clinical endocrinology

authors： Radetti G,Buzi F,Cassar W,Paganini C,Stacul E,Maghnie M

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:To assess the relationship between circulating leptin levels, bone mineral content and density in the elderly. DESIGN:A cross-sectional study. PATIENTS:A cohort of 92 men and 171 women, with ages ranging from 68 to 75 years, selected as a healthy and normal functioning group, in the city centre of Verona. ...

journal_title：Clinical endocrinology

authors： Zoico E,Zamboni M,Adami S,Vettor R,Mazzali G,Tosoni P,Bissoli L,Bosello O

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:Recent studies have shown that Graves' disease (GD) is linked to and associated with alleles of the cytotoxic T lymphocyte antigen-4 (CTLA4) locus. However, the true pathogenic polymorphism(s) at this locus remains uncertain. Moreover, the association studies of the promoter CTLA4(-318)C/T polymorphism in whi...

journal_title：Clinical endocrinology

authors： Vaidya B,Oakes EJ,Imrie H,Dickinson AJ,Perros P,Kendall-Taylor P,Pearce SH

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Classical congenital adrenal hyperplasia (CAH) is characterized by a defect in cortisol and aldosterone secretion, adrenal hyperandrogenism, impaired adrenal medullary function and insulin insensitivity. The latter along with the increased tendency towards obesity raises questions whether other cardiovascula...

journal_title：Clinical endocrinology

authors： Roche EF,Charmandari E,Dattani MT,Hindmarsh PC

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVE:Low growth hormone (GH) secretion and hypogonadism are common in patients with Prader-Willi syndrome (PWS). In this study we present the effects of GH treatment on body composition and metabolism in adults with PWS. PATIENTS AND MEASUREMENTS:Nineteen patients with clinical PWS were recruited, 13 had PWS geno...

journal_title：Clinical endocrinology

authors： Höybye C,Hilding A,Jacobsson H,Thorén M

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVE:The molecular events leading to the development of GH-secreting pituitary tumours remain largely unknown. Gsalpha (GNAS1) mutations are found in 27-43% of sporadic GH-secreting adenomas in the Caucasian population, but the frequency of GNAS1 mutations in Japanese and Korean acromegalic patients was reported t...

journal_title：Clinical endocrinology

authors： Yamasaki H,Mizusawa N,Nagahiro S,Yamada S,Sano T,Itakura M,Yoshimoto K

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVES:Constitutional delay in growth and adolescence (CDGA) is common in boys, some of whom request treatment to accelerate growth and attainment of secondary sexual characteristics. The aims of this study were to confirm that a 3-month course of intramuscular testosterone oenanthate does not impair final height i...

journal_title：Clinical endocrinology

authors： Kelly BP,Paterson WF,Donaldson MD

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:We evaluated menopausal symptoms, menstrual cycle bleeding characteristics and reproductive hormones for their associations with thyroid stimulating hormone (TSH) concentrations in women at the mid-life from five ethnic groups. METHODS:This report is from the baseline evaluation of the Study of Women's Healt...

journal_title：Clinical endocrinology

authors： Sowers M,Luborsky J,Perdue C,Araujo KL,Goldman MB,Harlow SD,SWAN.

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:Reduction of plasma free fatty acids leads to enhanced GH response after stimulation by GH-releasing hormone (GHRH). We studied the clinical usefulness of combined administration of acipimox and GHRH for the diagnosis of GH deficiency. DESIGN:We evaluated 35 patients [mean age 53.0 years; mean body mass inde...

journal_title：Clinical endocrinology

authors： van Dam PS,Dieguez C,Cordido F,de Vries WR,Veldhuyzen BF,van Thiel E,Casanueva FF,Koppeschaar HP

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:To compare the relative utility of GH secretion via pharmacological stimulation, overnight serial sampling, IGF-I levels and auxological variables as predictors of change in height standard deviation score (deltaHt SDS) during GH treatment. DESIGN:A multicentre observational study. PATIENTS:Prepubertal chil...

journal_title：Clinical endocrinology

authors： Rogol AD,Blethen SL,Sy JP,Veldhuis JD

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Autoimmune thyroiditis is one of the most common autoimmune disorders. Autoantibodies against the thyroid gland, with thyroid peroxidase antibody (TPO-Ab) and thyroglobulin antibody (Tg-Ab) as the most common autoantibodies, can often be demonstrated in serum in population surveys. In the present st...

journal_title：Clinical endocrinology

authors： Pedersen IB,Knudsen N,Jørgensen T,Perrild H,Ovesen L,Laurberg P

更新日期：2003-01-01 00:00:00

abstract：:Familial neurohypophysial diabetes insipidus (FNDI) is a rare autosomal dominant syndrome stemming from the absence of arginine vasopressin (AVP). More than thirty-five different germline mutations in the arginine vasopressin-neurophysin II gene have been reported. These mutations are either in the signal peptide or s...

journal_title：Clinical endocrinology

authors： Boson WL,Sarubi JC,d'Alva CB,Friedman E,Faria D,De Marco L,Wajchenberg B

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Disturbances in the GH/IGF-I axis are reported in 25-60% of short children born small for gestational age (SGA). We hypothesized that these abnormalities might be related to abnormalities in the pituitary region. Therefore, the results of magnetic resonance imaging (MRI) of short SGA children were compared t...

journal_title：Clinical endocrinology

authors： Arends NJ,V d Lip W,Robben SG,Hokken-Koelega AC

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:IGF-I has important actions on cell division, apoptosis, differentiation and metabolism, as well as on cell proliferation in vascular smooth muscle. Deficiency of GH, an important regulator of IGF-I, is associated with reduced well-being. IGF-I levels have been related to cognitive function in older individua...

journal_title：Clinical endocrinology

authors： Unden AL,Elofsson S,Knox S,Lewitt MS,Brismar K

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:Over 1% of the UK population is receiving thyroid hormone replacement with l-thyroxine (T4). However, many patients complain of persistent lethargy and related symptoms on T4 even with normal TSH levels. To date there has been no large study to determine whether this is related to thyroxine replacement or coi...

journal_title：Clinical endocrinology

authors： Saravanan P,Chau WF,Roberts N,Vedhara K,Greenwood R,Dayan CM

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:Nonuniformity in suppression of spermatogenesis induced by various hormones or hormone combinations has impeded the development of an effective hormonal male contraceptive. The basis for this heterogeneity in response remained unresolved to date; however, the presence of ethnic differences points to an involv...

journal_title：Clinical endocrinology

authors： Eckardstein SV,Schmidt A,Kamischke A,Simoni M,Gromoll J,Nieschlag E

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR) gamma gene has been associated in some, but not all, studies with lower body mass index (BMI) and improved insulin sensitivity; how an altered transcriptional activity of PPARgamma2 could influence insulin sensitivity is curre...

journal_title：Clinical endocrinology

authors： Vaccaro O,Mancini FP,Ruffa G,Sabatino L,Iovine C,Masulli M,Colantuoni V,Riccardi G

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVE:To determine whether treatment with transdermal oestrogen replacement therapy (TERT) in postmenopausal women with type 2 diabetes mellitus was able to increase the activity of constitutive nitric oxide synthase (cNOS) in platelets. RESEARCH DESIGN AND METHODS:Eighteen postmenopausal women with type 2 diabete...

journal_title：Clinical endocrinology

authors： Martina V,Bruno GA,Origlia C,Gaia D,Trucco F,Pescarmona G

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:This study was designed to investigate whether an elevated serum antithyroglobulin antibody (TgAb) reflects cancer recurrence in thyroglobulin (Tg)-undetectable patients with differentiated thyroid carcinoma (DTC) after thyroid ablation. DESIGN:We measured serum TgAb level and evaluated the disease status in...

journal_title：Clinical endocrinology

authors： Chung JK,Park YJ,Kim TY,So Y,Kim SK,Park DJ,Lee DS,Lee MC,Cho BY

更新日期：2002-08-01 00:00:00

abstract：:Seckel syndrome is an autosomal-recessive disorder with a frequency of less than 1/10 000 births in which there are multiple malformations including severe short stature. We report on a patient with Seckel syndrome with a current body height of -7.5 SDS. Laboratory investigations at the age of 19 months revealed high ...

journal_title：Clinical endocrinology

authors： Schmidt A,Chakravarty A,Brommer E,Fenne BD,Siebler T,De Meyts P,Kiess W

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:In patients with acromegaly serum IGF-I is increasingly used as a marker of disease activity. As a result, the relationship between serum GH and IGF-I is of profound interest. Healthy females secrete three times more GH than males but have broadly similar serum IGF-I levels, and women with GH deficiency requ...

journal_title：Clinical endocrinology

authors： Parkinson C,Renehan AG,Ryder WD,O'Dwyer ST,Shalet SM,Trainer PJ

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:This study was designed in order to evaluate bone turnover with bone formation and resorption markers in hyperthyroidism and its possible relationship with serum cytokines interleukin 6 (IL-6) and tumour necrosis-alpha (TNF-alpha), levels of thyroid hormones and thyroid autoantibodies. DESIGN AND PATIENTS:Tw...

journal_title：Clinical endocrinology

authors： Akalin A,Colak O,Alatas O,Efe B

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:It is still difficult to differentiate pituitary adenoma remnants from postradiotherapy fibrosis by computed tomography (CT) or magnetic resonance imaging (MRI), especially in patients with clinically nonfunctioning pituitary adenomas (NFA), lacking circulating markers to follow disease progression or cure. ...

journal_title：Clinical endocrinology

authors： Colao A,Ferone D,Lombardi G,Lastoria S

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:It has been well documented that treatment of chronic hepatitis B and C infection with interferon alpha (IFN-alpha) can lead to the induction of thyroid autoantibodies and hypothyroidism. Thyrotoxicosis, however, is less frequently observed and less well characterized. PATIENTS AND METHODS:We ...

journal_title：Clinical endocrinology

authors： Wong V,Fu AX,George J,Cheung NW

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVES:The differentiation of constitutional delayed puberty (CDP) from gonadotrophin deficiency (GD) in boys at referral poses a difficult challenge. The effectiveness of the GnRH agonist (GnRH-a) test in distinguishing between the two conditions was evaluated and compared with findings of the GnRH and hCG stimula...

journal_title：Clinical endocrinology

authors： Kauschansky A,Dickerman Z,Phillip M,Weintrob N,Strich D

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:Because there is discordance between different immunoassay values for serum hGH, and because clinical state may not correlate with immunoreactive hGH, we have developed an assay to accurately measure serum hGH somatogenic bioactivity. The results of this assay were compared with the Elegance two-site ELISA as...

journal_title：Clinical endocrinology

authors： Rowland JE,Marshall NJ,Leung KC,Ho KK,Cotterill AM,Rowlinson SW,Waters MJ

更新日期：2002-04-01 00:00:00

abstract：:Malignant insulinomas are very rare endocrine tumours with a variable clinical course. We describe a 51-year-old man who had two large insulinomas resected from the body of the pancreas and 19 years later, having again become symptomatic, was found to have hepatic metastases. Medical treatment with diazoxide and octre...

journal_title：Clinical endocrinology

authors： Scott A,Hinwood D,Donnelly R

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVES:To optimize the indications for treating girls with idiopathic central precocious puberty with GnRH analogues, since outcomes may vary. DESIGN:Comparison of adult heights with the data at initial evaluation and the target heights. PATIENTS:Group 1 patients (n = 43) were treated with GnRH analogue from 7.9 ...

journal_title：Clinical endocrinology

authors： Adan L,Chemaitilly W,Trivin C,Brauner R

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:Surgery of bone metastases from differentiated thyroid carcinoma seems indicated in individual patients. This study was performed (1) to analyse retrospectively patients with bone metastases from differentiated thyroid carcinoma and (2) to evaluate the impact of surgery of bone metastases on survival. PATIEN...

journal_title：Clinical endocrinology

authors： Zettinig G,Fueger BJ,Passler C,Kaserer K,Pirich C,Dudczak R,Niederle B

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:Hypercortisolism is associated with impaired glucose tolerance and insulin resistance. For many years hydrocortisone 30 mg was the standard total daily replacement dose in adult hypopituitarism. The use of this conventional dose has now been shown to result in mild biochemical hypercortisolism and might contr...

journal_title：Clinical endocrinology

authors： McConnell EM,Bell PM,Ennis C,Hadden DR,McCance DR,Sheridan B,Atkinson AB

更新日期：2002-02-01 00:00:00

abstract：:Myotonic dystrophy (MyD) is a common genetic neuromuscular disorder in which chromosome 19 gives rise to an abnormal expansion of CTG-trinucleotide repeats. MyD is a highly variable multisystem disorder with muscular and nonmuscular abnormalities. Increasingly, endocrine abnormalities, such as gonadal, pancreatic, and...

journal_title：Clinical endocrinology

authors： Misra D,DeSilva S,Fellerman H,Dufour DR,Streeten DH,Nylen ES

更新日期：2002-02-01 00:00:00

abstract：:A review of the genetics of male undermasculinization must encompass a description of the embryology of the genital system. The dimorphism of sex development consequent upon the formation of a testis and the subsequent secretion of hormones to impose a male phenotype is highlighted. Thus, an understanding of the cause...

journal_title：Clinical endocrinology

authors： Ahmed SF,Hughes IA

更新日期：2002-01-01 00:00:00